Cerebellar Research - D. Timmann

Cerebellar Research

D. Timmann
AtaxisCerebellum
Group Banner - D. Timmann

Dagmar Timmann’s group has a long-standing interest to understand the physiology and pathophysiology of the human cerebellum. We investigate the involvement of the human cerebellum in motor, emotional and cognitive functions. We are interested whether the cerebellum is involved in particular forms of learning, which cerebellar areas participate and what the mechanisms of cerebellar involvement are.

A current focus of our research is to understand the contribution of the cerebellum to extinction processes. Structural and functional magnetic resonance imaging (MRI) is used in healthy participants and patients with different forms of ataxias. The excellent signal-to-noise-ratio of 7T MRI allows us to study cerebellar function at the level of the cerebellar cortex and cerebellar nuclei.

Current projects
  • DFG: SFB 1280 "Extinction Learning" 2021 - 2025, Project number 316803389, Deputy Speaker, PI of the research projects A05 "The contribution of the cerebellum to extinction: intrinsic mechanisms and cerebello-cerebral interactions" and F02 "Focus Group Neuroimaging and Genetics"
  • EU: Marie Skłodowska-Curie Innovative Training Network: Cerebellum and emotional networks (CEN), Deputy Network Coordinator, PI 2021 - 2025, Project number: 956414
  • EU: Spinocerebellar ataxias: Advanced imaging with ultra-high field MRI (SCAIFIELD) 2021 - 2024, Funded by EU Joint Program - Neurodegenerative Disease Research (JPND), Project number: 01ED2109A, Deputy Speaker
Selected Publications
  • Batsikadze G, N Diekmann, TM Ernst, et al., The cerebellum contributes to context-effects during fear extinction learning: A 7T fMRI study., Neuroimage (2022)
  • Deistung A, D Jäschke, R Draganova, et al., Quantitative susceptibility mapping reveals alterations of dentate nuclei in common types of degenerative cerebellar ataxias., Brain Commun (2022)
  • Ernst TM, AE Brol, M Gratz, et al., The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm., Elife (2019)
  • Ernst TM, M Thürling, S Müller, et al., Modulation of 7 T fMRI Signal in the Cerebellar Cortex and Nuclei During Acquisition, Extinction, and Reacquisition of Conditioned Eyeblink Responses., Hum Brain Mapp (2017)
  • Stefanescu MR, M Dohnalek, S Maderwald, et al., Structural and functional MRI abnormalities of cerebellar cortex and nuclei in SCA3, SCA6 and Friedreich's ataxia., Brain (2015)
  • Thürling M, F Kahl, S Maderwald, et al., Cerebellar cortex and cerebellar nuclei are concomitantly activated during eyeblink conditioning: a 7T fMRI study in humans., J Neurosci (2015)
  • Burciu RG, N Fritsche, O Granert, et al., Brain changes associated with postural training in patients with cerebellar degeneration: a voxel-based morphometry study., J Neurosci (2013)
  • Thürling M, H Hautzel, M Küper, et al., Involvement of the cerebellar cortex and nuclei in verbal and visuospatial working memory: a 7 T fMRI study., Neuroimage (2012)
  • Thürling M, M Küper, R Stefanescu, et al., Activation of the dentate nucleus in a verb generation task: A 7T MRI study., Neuroimage (2011)
  • Diedrichsen J, S Maderwald, M Küper, et al., Imaging the deep cerebellar nuclei: a probabilistic atlas and normalization procedure., Neuroimage (2011)
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