RF manipulation - M. E. Ladd

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RF manipulation

M. E. Ladd
Methodological advances in magnetic resonance imaging and spectroscopyRadiofrequency hardwareParallel transmissionMRI safety
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Our research group develops methods and technologies to enable 7 Tesla examinations throughout the body including the torso. Part of the work is performed at the Erwin L. Hahn Institute (ELH) in Essen and part at the German Cancer Research Center (DKFZ) in Heidelberg.

Our work is in particular focused on:

  • multi-channel transmit coils,
  • numerical simulations in inhomogeneous human body models to investigate B1 and SAR patterns, and
  • excitation strategies to homogenize the transmit B1 field or perform spatially selective excitation/saturation.

A 32-channel parallel transmission system is under development as part of a collaboration between the ELH in Essen and DKFZ in Heidelberg. We work closely with other groups at the ELH, including Tom Scheenen on prostate imaging and Harald Quick on RF technology.

Selected Publications
  • Fiedler TM, S Orzada, M Flöser, et al., Performance and safety assessment of an integrated transmit array for body imaging at 7 T under consideration of specific absorption rate, tissue temperature, and thermal dose., NMR Biomed (2022)
  • Korzowski A, N Weckesser, VL Franke, et al., Mapping an Extended Metabolic Profile of Gliomas Using High-Resolution 31P MRSI at 7T., Front Neurol (2021)
  • Platt T, ME Ladd, D Paech, 7 Tesla and Beyond: Advanced Methods and Clinical Applications in Magnetic Resonance Imaging., Invest Radiol (2021)
  • Kratzer FJ, S Flassbeck, S Schmitter, et al., 3D sodium (23 Na) magnetic resonance fingerprinting for time-efficient relaxometric mapping., Magn Reson Med (2021)
  • Voelker MN, O Kraff, S Goerke, et al., The traveling heads 2.0: Multicenter reproducibility of quantitative imaging methods at 7 Tesla., Neuroimage (2021)
  • Orzada S, TM Fiedler, AK Bitz, et al., Local SAR compression with overestimation control to reduce maximum relative SAR overestimation and improve multi-channel RF array performance., MAGMA (2021)
  • Loi L, F Zimmermann, S Goerke, et al., Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T., Eur J Radiol (2020)
  • Orzada S, K Solbach, M Gratz, et al., A 32-channel parallel transmit system add-on for 7T MRI., PLoS One (2019)
  • Ladd ME, P Bachert, M Meyerspeer, et al., Pros and cons of ultra-high-field MRI/MRS for human application., Prog Nucl Magn Reson Spectrosc (2018)
  • Paech D, J Windschuh, J Oberhollenzer, et al., Assessing the predictability of IDH mutation and MGMT methylation status in glioma patients using relaxation-compensated multipool CEST MRI at 7.0 T., Neuro Oncol (2018)
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